How is God going to work out his plans if humans are so disloyal to Him even though they have the Holy Spirit?

In hope we are saved (Romans 8:24)

I saw this question recently: It doesn't seem as if God's plans are working out too well. Humans are loyal to him; only Jesus has been. The Holy Spirit doesn't seem to be making much of a difference. So how is God going to have loyal human partners and work out his plans?

But this question misunderstands the entire storyline of the Bible.